Additive compatibility drugs in syringe compatibility. We have also added stability and compatibility information for three new drug products. Ketorolac tromethamine toradol, a nonsteroidal antiinflammatory drug nsaid, is commonly used alone or in combination with other analgesics for pain management in both hospital inpatients and outpatients. Sold under names such as toradol and ketorolac tromethamine tables, it is most often used to treat pain following a procedure, but it can also be used to relieve back pain, cancer pain, and pain caused by kidney stones.
Dec 16, 2016 for acute pain in the ed, parenteral ketorolac is generally administered as 30 mg iv or 60 mg im. Ketorolac tromethamine is a nonsteroidal antiinflammatory drug nsaid used for the shortterm relief of moderate to severe pain. Comparison of intravenous ketorolac at three singledose. Favorites subscribe to favorite the drugs you use most often for quick access. Substitutes and alternatives to toradol ketorolac for uses like pain, postoperative ocular pain and inflammation after eye surgery and ocular itching.
Ketorolac has mild interactions with at least 78 different drugs. A aripiprazole, caspofungin acetate, and ropivacaine hydrochloride. Shortening the recommended dosing intervals may result in increased frequency and severity of adverse reactions. Ketorolac is used for the shortterm relief of moderately severe pain and should not be used for longer than 5 days, for mild pain, or for pain from chronic longterm conditions. Ketorolac tromethamine is prescribed for the treatment of allergic conjunctivitis pink eye, post operative inflammation pain, burning, and stinging after eye surgery such as cataract surgery or corneal. Comparison of intravenous ketorolac at three singledose regimens for treating acute pain in the emergency department. This information does not contain all possible interactions or adverse effects.
Intravenous iv preparation and infusion guidelines globalrph. This reference contains standard dilutions including iv admixture drug concentration, infusion volumes, and infusion rates. Its bioavailability and dosage are similar for im and iv administration after cesarean delivery, the efficacy of im. The smarter search functionality includes a single search box on. Compatibility is denoted by an icon and simple description. Intravenous iv dilution ketorolac tromethamine toradol intravenous dilution protocols and pharmacology from globalrph.
Jan 07, 2019 the combined duration of use of parenteral, oral, and nasal ketorolac should not exceed 5 days. Compatibility and stability of ketorolac tromethamine and. Compatibility of ketorolac tromethamine injection with. Find patient medical information for ketorolac intravenous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Ketorolac tromethamine and morphine hydrochloride were mixed together in 0. At the first sign of itching of throat or skin, stop using it. The oral tablets are only indicated as continuation treatment after iv or im administration, if necessary. Stability of ketorolac tromethamine in iv solutions and. Ketorolac is a nonsteroidal antiinflammatory drug nsaid. In the eye prostaglandin is involved in inflammation, pain, and irritation due to allergies or mechanical injury. There are no stability data for periods beyond 48 h for ketorolac diluted in iv fluids.
Therefore, before using this product, tell your doctor or pharmacist of all the products you use. It is also used to treat pain, burning, and inflammation of the eye following cataract surgery or corneal refractive surgery. Ketorolac tromethamine is available for intravenous iv or intramuscular im administration as. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the u. Although ketorolac is approved for im use, iv administration after orthopedic surgery has increased its use. Ketorolac tromethamine eye drops acular, acuvail uses.
Ns or d5w preferred diluent for acetaminophen overdose acyclovir. Last, we administered the medication intravenously, and many studies from which the nnts were obtained used the intramuscular route. Other analgesics were standardized between groups intravenous fentanyl in the recovery ward and oral codeine in the day stay unit. Oct 29, 2010 study of whether 15 mg dose of ketorolac iv is as effective as a 30 mg dose. Toradol ketorolac side effects, dosage, interactions. Ketorolac is a nonsteroidal antiinflammatory drug similar to ibuprofen, indomethacin, naproxen, and many others. Ketorolac has similar analgesic efficacy at intravenous doses of 10, 15, and 30 mg, showing that intravenous ketorolac administered at the analgesic ceiling dose 10 mg provided effective pain relief to ed patients with moderate to severe pain without increased adverse effects. At 30 minutes, substantial pain reduction was demonstrated without any differences between the groups 95% confidence intervals 4.
The compatibility of ketorolac tromethamine injection with commonly used i. Comparison of iv, im and oral pharmacokinetics the pharmacokinetics of ketorolac tromethamine, following iv, im and oral doses of ketorolac tromethamine are compared in table 1. Food can decrease peak and delay timetopeak concentrations. Subscribe to plumbs veterinary drugs to create and save personal notes for every drug you use. Comparison of morphine, ketorolac, and their combination. Other drugs in this class include ibuprofen and naproxen naprosyn, aleve, but ketorolac is more effective than other nsaids in reducing pain from both inflammatory and noninflammatory causes.
Reviewed toradol on 832019 as with any medications used for pain, this one is a favorite in ers and by some surgeons. Ketorolac is used for the shortterm treatment of moderate to severe pain. Toradol im injection, iv injection information from. Iv drug compatibility chart k ketorolac tromethamine alteplase activase, rtpa amiodarone cordarone argatroban atropine calcium chloride diltiazem cardizem dobutamine dobutrex dopamine epinephrine adrenalin esmolol brevibloc furosemide lasix heparin insulin regular lidocaine xylocaine lorazepam ativan magnesium sulfate. Each monograph contains stability data, administration guidelines, and methods of preparation. Ketorolac may also be used for purposes not listed in this medication guide. Compatibility of ketorolac tromethamine injection with common infusion fluids and administration sets. Therapy should always be initiated with iv or im dosing of ketorolac tromethamine, and toradol ketorolac tromethamine oral is to be used only as. Trissel, fashp, 2010, american society of healthsystem pharmacists. Stability of ketorolac tromethamine in iv solutions and waste. Comparison of iv, im and oral pharmacokinetics the pharmacokinetics of ketorolac tromethamine, following iv and im doses of ketorolac tromethamine and oral doses of toradol, are compared in table 1. Study of whether 15 mg dose of ketorolac iv is as effective. It is usually used before or after medical procedures or after surgery.
Notably, the american association of pediatrics finds ketorolac compatible with breastfeeding. Ketorolac tromethamine injection, usp is available for intravenous iv or intramuscular im administration as. See what others have said about ketorolac, including the effectiveness, ease of use and side effects. For solution and drug compatibility information, see compatibility under stability. Toradol ketorolac side effects, dosage, interactions drugs. Toradol is in a group of drugs called nonsteroidal antiinflammatory drugs nsaids.
This medicine is a topical nonsteroidal antiinflammatory drug nsaid. Ketorolac tromethamine acular, acular ls, acuvail is a nsaid medication similar to other nsaids like ibuprophen, naproxen, and many others. Hotoffthepress is a new randomized, doubleblind trial from dr. Parenteral ketorolac has been used concomitantly with opiate agonist analgesics e. Prostaglandins have many effects in the body including their role in pain and inflammation. Vchphc revised june 2009 syringe compatibility chart use within 15 minutes atropine benztropine chlorpromazine codeine dimenhydrinate diphenhydramine droperidol fentanyl glycopyrrolate haloperidol hydromorphone hydroxyzine lorazepam meperidine methotrimeprazine metoclopramide midazolam morphine prochlorperazine. Nov 28, 2019 ketorolac tromethamine injection, usp is available for intravenous iv or intramuscular im administration as. It is typically given before or after medical procedures or after surgery. The role of subcutaneous ketorolac for pain management. Study of whether 15 mg dose of ketorolac iv is as effective as a 30 mg dose. Although the onset of action of ketorolac and morphine is similar, ketorolac has a longer halflife, 5ampersandnumbersignx020. Drug interactions with ketorolac can increase your risk of serious side effects, make some drugs less effective, and cause your body to metabolize the drugs differently than intended, among other things. Limit duration of use so the total combined duration of oral and parenteral ketorolac.
Home drugs a to z t to toradol consumer information print save or share toradol generic name. Jan 26, 2006 ketorolac tromethamine is available for intravenous iv or intramuscular im administration as. Ketorolac eye drops is used to treat itching caused by seasonal allergic conjunctivitis an allergy that occurs at only certain times of the year. Ketorolac dosing, indications, interactions, adverse. A also included in this update are compatibility information for cefepime, ganciclovir, ketamine, ketorolac, and nesiritide. Dailymed ketorolac tromethamine ketorolac tromethamine. Ketorolac reduces the production of prostaglandins, chemicals that. The iv drug compatibility chart is based on information from the handbook of injectable drugs, 16th edition, by lawrence a. Ketorolac oral route, injection route precautions mayo clinic.
The opioidsparing effects of intravenous ketorolac as an adjuvant. Ketorolac tromethamine monograph for professionals. Ketorolac dosing, indications, interactions, adverse effects, and more. Ketorolac systemic drug monograph pediatric care online. The ceiling effect of iv ketorolac the pharmertoxguy. Our ketorolac products include tablets, ophthalmic solutions and injections.
The effect of intravenous ketorolac on opioid requirement. A few of the drugs that can potentially interact with ketorolac. A legend at the bottom of the page lists all compatibility types, and hovering your mouse over the icon will open a popup with the full. Toradol ketorolac is used to relieve shortterm, moderatetosevere pain in adults. Oral ketorolac therapy is only indicated as continuation therapy to iv im therapy. Ketorolac tromethamine injection, usp for intramuscular and intravenous use is available as. Iv compatibility results are organized onto separate tabs, so that you can quickly access the route or method in which you are interested. Ketorolac dosing, indications, interactions, adverse effects. Dailymed ketorolac tromethamine injection, solution. Compatibility of ketorolac tromethamine injection with common. Ketorolac, a nonselective inhibitor of the cyclooxygenase cox enzyme, prevents the synthesis of prostaglandins and thromboxanes from arachidonic acid. Our online store features the generic drug from several different manufacturers such as hospira, sun pharmaceutical industries, teva and wockhardt pharmaceuticals. Ketorolac is used shortterm 5 days or less to treat moderate to severe pain. It produces postoperative analgesia comparable to systemic opioids, but has a ceiling effect.
Check out these bestsellers and special offers on books and newsletters from mayo clinic. Systemic use of ketorolac is only indicated for the shortterm management of moderately severe acute pain that requires analgesia at the opioid level. Feb 20, 2015 patients received either ketorolac 10. Ketorolac works by reducing hormones that cause inflammation and pain in the body.
Ketorolac tromethamine tablets ketorolac tromethamine. Ketorolac tromethamine tablets ketorolac tromethamine dose. Syntex, dee why, new south wales is a pyrrole acetic acid nonsteroidal antiinflammatory drug nsaid designed for parenteral administration. Stability and compatibility of the mixture of tramadol.
1484 812 243 1197 703 1600 551 281 585 95 1322 443 333 1185 1026 1520 681 1237 290 650 987 1620 1535 92 744 938 606 1068 793 1476 997 812 105 21 684 545 1157 813 251 1430 1203 157 702 913 852